In These rats educated to self-administer oxycodone, administration of an immunoconjugate vaccine (Oxy-TT) diminished oxycodone concentrations in brain by 50% and vaccination reduced the rat's oxycodone intake and presented safety from the reinforcing effects of oxycodone. The precise neuronal pathways that bring on opioid addiction and abuse want further investigating. https://wockusa.com/product/actavis-promethazine-codeine/