TAK-243 preferentially sure to UBA1 over the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 reduced amounts of ubiquitylated proteins, amplified markers of proteotoxic anxiety and DNA damage strain. In vivo, TAK-243 decreased leukemic stress and focused leukemic stem cells devoid of https://tonyk308zei1.onzeblog.com/profile